I’ve tried several RAMDisk softwares before I found one that were free and worked under Windows 10 64-Bit.
The RAMDisk I use is called ImDisk Toolkit, and I find it pretty much perfect. It got plenty of features which should cover pretty much every users needs.
It might also save a lot of write cycles on your precious SSDs. 😉
You can set it up to mount ISO-files and other image file formats if you want to.
Or setup a folder on one of your hard drives and have the content inside it copied to the RAMDisk every time you boot up your PC.
It can also be setup to save the stuff you currently got stored on the RAMDisk to a directory of your choice before you shut down your PC.